Phage-derived 12/1 peptide

Phage-derived 12/1 peptide demonstrates antitumor activity by targeting MDM2 and MDMX, thereby disrupting the MDM2-p53 and MDMX-p53 interactions, with IC50 values of 0.15 and 1.25 μM, respectively [1].

C([C@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC(=O)[C@H]3N(C([C@H](CCSC)N)=O)CCC3)CCCNC(=N)N)=O)=O)CCSC)=O)CC(O)=O)=O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)CC(C)C)=O)=O)CCC(O)=O)=O)C=4C=5C(NC4)=CC=CC5