PD 156252

PD 156252 is a hexapeptide and a highly potent endothelin (ET) antagonist, exhibiting enhanced binding affinity for rabbit ETA and rat ETB receptor subtypes with IC50 values of 1.0 nM and 40 nM, respectively.

[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N([C@H](C(N[C@@H](CC=1C=2C(NC1)=CC=CC2)C(O)=O)=O)[C@H](CC)C)C)=O)[C@H](CC)C)=O)CC(O)=O)=O)CC(C)C)=O)(NC(C)=O)C3C=4C(CCC=5C3=CC=CC5)=CC=CC4