Human GIP (3-30), amide

Human GIP (3-30), amide is a high-affinity human GIP receptor antagonist and a natural metabolite of DPP-4 cleavage of GIP (1-30) NH2. Human GIP (3-30), amide inhibits insulin secretion in vitro and suppresses cAMP and β-arrestin 1/2 recruitment induced by GIP (1-42) .

C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CCC(N)=O)=O)C)=O)CC(C)C)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC(CNC([C@H](CCC(O)=O)N)=O)=O)[C@@H](C)O)=O)=O)[C@H](CC)C)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)[C@H](CC)C)=O)C)=O)CCSC)=O)CC(O)=O)=O)CCCCN)=O)[C@H](CC)C)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CC(O)=O)=O)=O)[C@@H](C)C)=O)CC(N)=O)=O)C=5C=6C(NC5)=CC=CC6