APT STAT3

APT STAT3 is a STAT3-binding peptide that displays high specificity and affinity for STAT3 (~231 nmol/L) . It serves as a tractable agent for targeting a wide range of cancers with constitutively activated STAT3 [1].

C([C@@H](C(=O)N1[C@H](C(NCC(N[C@H](C(N[C@@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC=6C=7C(NC6)=CC=CC7)C(N[C@H](C(N[C@@H](CC=8C=9C(NC8)=CC=CC9)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC%10=CC=C(O)C=C%10)C(N[C@H](C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CC(C)C)=O)=O)CCC(N)=O)=O)=O)C)=O)=O)CCCCN)=O)=O)[C@@H](C)O)=O)=O)CCCCN)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)=O)CO)=O)=O)CCC1)NC([C@@H](NC([C@H](CC%12=CC=CC=C%12)NC(CNC([C@H](CC%13=CN=CN%13)N)=O)=O)=O)CCC(N)=O)=O)C=%14C=%15C(NC%14)=CC=CC%15