Cypemycin

Cypemycin, a linaridin antibiotic, demonstrates the capability to inhibit cancer cell activity. It has an inhibitory IC50 of 1.3 μg/mL against P388 leukemia cells, while its inhibitory IC50 exceeds 25 μg/mL for human tumor cells such as HeLa S3, HHCC-1, HCCS-M, and Slex.

C(N/C(/C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N/C(/C(N[C@H](C(N[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](C)C)C(=O)N/C=C\SC2)=O)[C@@H](CC)C)=O)=C/C)=O)CO)=O)=O)CCC(N)=O)=O)[C@@H](CC)C)=O)[C@H](C)C)=O)=O)CCC(N)=O)=O)C)=O)C(C)C)=O)=C/C)(=O)[C@H]3N(C(/C(/NC([C@@H](NC(=O)[C@H]4N(C(/C(/NC([C@@H](N(C)C)C)=O)=C\C)=O)CCC4)C)=O)=C\C)=O)CCC3