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Nocarnickelamides B

Product Specifications

Target

Myosin|||ROCK

Related Pathways

Cytoskeletal Signaling|||Stem Cells|||Cell Cycle/Checkpoint

Bioactivity

Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 ?M and 21.9 ?M, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.

Smiles

CCCCCc1ccccc1

Molecular Formula

C11H16

Molecular Weight

148.249

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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