Nocarnickelamides B
Product Specifications
Target
Myosin|||ROCK
Related Pathways
Cytoskeletal Signaling|||Stem Cells|||Cell Cycle/Checkpoint
Bioactivity
Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 ?M and 21.9 ?M, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.
Smiles
CCCCCc1ccccc1
Molecular Formula
C11H16
Molecular Weight
148.249
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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