Asterriquinone
Product Specifications
CAS Number
60696-52-8
Target
Reverse Transcriptase|||EGFR|||HIV Protease
Related Pathways
Microbiology/Virology|||JAK/STAT signaling|||Proteases/Proteasome|||Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
Asterriquinone (ARQ) is an analog of Asterriquinone and a Grb-2 binding inhibitor. It hinders the interaction between Grb-2 and tyrosine-phosphorylated EGFR, with an IC50 of 8.37 ?M. Additionally, Asterriquinone serves as an HIV1 reverse transcriptase inhibitor, with a Ki of 2.3 ?M, and it also inhibits the binding activities of Grb-7 and PLC-?.
Smiles
O=C1C(O)=C(C(=O)C(O)=C1C2=CN(C=3C=CC=CC23)C(C=C)(C)C)C4=CN(C=5C=CC=CC45)C(C=C)(C)C
Molecular Formula
C32H30N2O4
Molecular Weight
506.592
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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