Arborcandin A

Arborcandin A is a 1,3-?-glucan synthase inhibitor, acting as an antifungal antibiotic. It exhibits IC50 values of 0.25 ?g/mL against Candida albicans (C. albicans) and 0.05 ?g/mL against Aspergillus fumigatus (A. fumigatus) . The MIC for the Candida species is 4-8 ?g/mL.

C(C(C(N)=O)O)C1C(=O)N[C@]([C@@H](C)O)(C(=O)N[C@@]([C@@H](C)O)(C(=O)NC(CCC(CCCCCCCCC)O)C(=O)NCC(=O)NCCC(=O)NC(CCCCCCCC(CCCC)O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C)C(=O)N1)[H])[H]