Glucopiericidin A
Product Specifications
CAS Number
108073-65-0
Target
Transporter, ADC Cytotoxin, Apoptosis
Related Pathways
Apoptosis, Metabolism, Antibody-drug Conjugate/ADC Related
Bioactivity
Glucopiericidin A is a natural piperidine-based compound found in marine-derived Streptomyces strains. It serves as a chemical probe for glucose transporter proteins (GLUT) and can inhibit glycolysis. When combined with Piericidin A (PA), it synergistically inhibits ATP-dependent filopodia formation, yet has no effect alone. Glucopiericidin A induces apoptosis by increasing PRDX1, thereby reducing reactive oxygen species (ROS) levels, and also demonstrates potent antitumor activity in ACHN mouse xenografts.
Smiles
O([C@H]([C@@H](/C=C(/C=C/C/C(=C/CC=1N=C(OC)C(OC)=C(O)C1C)/C)\C)C)/C(=C/C)/C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
Molecular Formula
C31H47NO9
Molecular Weight
577.706
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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