Ardeemin
Product Specifications
CAS Number
148441-25-2
Target
P-gp
Related Pathways
Membrane transporter/Ion channel, Neuroscience
Bioactivity
Ardeemin ((-) -Ardeemin) binds to P-glycoprotein, inhibiting the efflux of anticancer drugs from cells. In breast cancer xenograft models, Ardeemin can reverse the multidrug resistance phenotype of tumor cells and enhance their sensitivity to anticancer drugs.
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[C@@](C=C)(C)(C)[C@]12[C@](N3[C@@](C1)(C=4N([C@H](C)C3=O)C(=O)C=5C(N4)=CC=CC5)[H])(NC=6C2=CC=CC6)[H]
Molecular Formula
C26H26N4O2
Molecular Weight
426.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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