4,4′-Secalonic acid D
Product Specifications
CAS Number
2265910-52-7
Target
Reactive Oxygen Species, PARP, Pyroptosis, Caspase, Apoptosis
Related Pathways
Immunology/Inflammation, NF-κB, Metabolism, Apoptosis, Proteases/Proteasome, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. By inhibiting PARP1, 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activating the caspase-3/GSDME pathway, which leads to tumor cell apoptosis (apoptosis) and pyroptosis (pyroptosis) . It exhibits antitumor activity.
Smiles
C(OC)(=O)[C@]12C(C(=O)C=3C(O1)=C(C=CC3O)C4=C5C(C(=O)C=6[C@@](C(OC)=O)(O5)[C@H](O)[C@@H](C)CC6O)=C(O)C=C4)=C(O)C[C@H](C)[C@H]2O
Molecular Formula
C32H30O14
Molecular Weight
638.572
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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