Cholesterol sulfate
Product Specifications
CAS Number
1256-86-6
Target
Glucocorticoid Receptor, Serine Protease, ROR
Related Pathways
Endocrinology/Hormones, Metabolism, Proteases/Proteasome
Purity
0.97
Bioactivity
Cholesterol sulfate is a multifunctional endogenous sterol sulfate and selective DOCK2 inhibitor with an IC50 of 2 μM in mouse assays. Cholesterol sulfate plays multiple roles including in epidermal barrier formation by regulating keratinocyte differentiation and corneocyte desquamation, functions as a serine-protease inhibitor, acts as a glucocorticoid receptor antagonist, and activates RORα/γ in the thymus. Cholesterol sulfate serves as a critical research tool for investigating cutaneous biology, immunomodulation, steroid metabolism, sperm capacitation, platelet aggregation, and disorders such as X-linked ichthyosis.
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C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC=C1C[C@@H](OS(=O)(=O)O)CC2)[H])[H]
Molecular Formula
C27H46O4S
Molecular Weight
466.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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