Cholesterol sulfate
Product Specifications
CAS Number
1256-86-6
Target
Glucocorticoid Receptor, Serine Protease, ROR
Related Pathways
Endocrinology/Hormones, Metabolism, Proteases/Proteasome
Purity
0.97
Bioactivity
Cholesterol sulfate is a multifunctional endogenous sterol sulfate and selective DOCK2 inhibitor with an IC50 of 2 μM in mouse assays. Cholesterol sulfate plays multiple roles including in epidermal barrier formation by regulating keratinocyte differentiation and corneocyte desquamation, functions as a serine-protease inhibitor, acts as a glucocorticoid receptor antagonist, and activates RORα/γ in the thymus. Cholesterol sulfate serves as a critical research tool for investigating cutaneous biology, immunomodulation, steroid metabolism, sperm capacitation, platelet aggregation, and disorders such as X-linked ichthyosis.
Smiles
C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC=C1C[C@@H](OS(=O)(=O)O)CC2)[H])[H]
Molecular Formula
C27H46O4S
Molecular Weight
466.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR15319083 1 Vial
Lentiviral human LRRC38 shRNA (UAS) - Lentiviral human LRRC38 shRNA (UAS, RFP) (100)
Sign In for Pricing
View Details orb2934076-01 20 µg
Recombinant African swine fever virus Protein H108R (Ken-129)
Sign In for Pricing
View Details orb2934076-02 100 µg
Recombinant African swine fever virus Protein H108R (Ken-129)
Sign In for Pricing
View Details