Stellettin B
Product Specifications
CAS Number
184885-91-4
Target
FAK, mTOR, PI3K, Autophagy, Apoptosis, Akt
Related Pathways
Apoptosis, PI3K/Akt/mTOR signaling, Angiogenesis, Cytoskeletal Signaling, Autophagy, Tyrosine Kinase/Adaptors
Bioactivity
Stellettin B, a triterpene compound isolated from the marine sponge Jaspis stellifera, has demonstrated notable anticancer properties. It induces G1 phase arrest, apoptosis, and autophagy in human non-small cell lung cancer A549 cells by inhibiting the PI3K/Akt/mTOR pathway. Additionally, Stellettin B reduces migration and invasion in hepatocellular carcinoma cells through the suppression of the MAPK and FAK/PI3K/AKT/mTOR signaling pathways. This compound is utilized in various cancer research studies.
Smiles
C[C@@]1\2[C@]([C@]3(C)[C@@](CC1)(C(C)(C)C(=O)CC3)[H])(CC(=O)/C2=C(\C=C\C=C(/C)\C=4OC(=O)C(C)=CC4)/C)[H]
Molecular Formula
C30H38O4
Molecular Weight
462.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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