3-Oxo-cinobufagin
Product Specifications
CAS Number
6869-66-5
Bioactivity
3-Oxo-cinobufagin (compound 8), a potential anticancer agent, is extracted from M. spinosus broth using high performance liquid chromatography. This compound is unique among its isolated counterparts because its C-5 hydroxyl group is further oxidized or isomerized, which significantly reduces its cytotoxic activity against most cell lines, except for HEL. However, it demonstrates increased activity in BEL cell strains. The IC50 values of 3-Oxo-cinobufagin for cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL) .
Smiles
C[C@]12[C@]3([C@](O3)([C@H](OC(C)=O)[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@](CC2)([C@]6(C)[C@](CC5)(CC(=O)CC6)[H])[H])[H]
Molecular Formula
C26H32O6
Molecular Weight
440.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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