Candidusin A
Product Specifications
CAS Number
81474-59-1
Target
NF-κB, Apoptosis, AMPK, TNF
Related Pathways
PI3K/Akt/mTOR signaling, NF-κB, Apoptosis, Chromatin/Epigenetic
Bioactivity
Candidusin A (CHNQD-0803) (Compound 4) is an AMPK activator with a KD of 47.28 nM. This compound can be isolated from the marine fungus Aspergillus candidus. Candidusin A exhibits cytotoxic activity against human prostate cancer cells (22Rv1, PC-3, and LNCaP cells) and induces apoptosis. It reduces lipogenic gene expression and fat deposition, downregulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and improves liver injury and fibrosis. Candidusin A is applicable in the study of non-alcoholic steatohepatitis (NASH) .
Smiles
OC=1C=CC(=CC1)C2=CC(OC)=C3C(OC4=CC(O)=C(O)C=C43)=C2OC
Molecular Formula
C20H16O6
Molecular Weight
352.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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