Coccinine
Product Specifications
CAS Number
485-57-4
Target
Serotonin Transporter, P-gp
Related Pathways
Membrane transporter/Ion channel, Neuroscience
Bioactivity
Coccinine ((-) -Coccinine) is a weak inhibitor of SERT with an IC50 of 196.3 μM and a Ki of 106.8 μM, and P-gp with an IC50 of 0.96 mM. It demonstrates significant antitumor activity against various cancer cell lines, including breast cancer (MCF7, Hs578T, MDA-MB-231), colon cancer (HCT-15), and lung cancer (A549) . Additionally, Coccinine is applicable in research involving tumors and neurological disorders.
Smiles
O(C)[C@@H]1C=C2[C@@]3(C=4C(C[N@@](C3)[C@]2(C[C@@H]1O)[H])=CC5=C(C4)OCO5)[H]
Molecular Formula
C17H19NO4
Molecular Weight
301.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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