Dichotomine C
Product Specifications
CAS Number
755036-45-4
Target
Interleukin|||TNF|||glycosidase
Related Pathways
Metabolism|||Apoptosis|||Immunology/Inflammation
Bioactivity
Dichotomine C ((R) - (-) -Dichotomine C) is a ?-carboline alkaloid with anti-allergic properties. It inhibits the release of ?-hexosaminidase from RBL-2H3 cells with an IC50 of 62 ?M. Additionally, it suppresses antigen IgE-mediated release of TNF-? and IL-4 in RBL-2H3 cells, with IC50 values of 19 ?M and 15 ?M, respectively. This compound is applicable in the research of type I hypersensitivity reactions.
Smiles
[C@@H](CO)(O)C1=C2C(C=3C(N2)=CC=CC3)=CC(C(OC)=O)=N1
Molecular Formula
C15H14N2O4
Molecular Weight
286.28
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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