MO-2097

MO-2097 is an inhibitor of RAF-1 and HIF-1α. It destabilizes RAF-1, reducing EMT-related transcription factors and mesenchymal markers. MO-2097 suppresses HIF-1α protein expression under hypoxic or hypoxia-mimicking conditions via hnRNPA2B1. It induces mitochondrial ROS production, leading to cell apoptosis. By inhibiting the RAF/MEK/ERK signaling pathway, MO-2097 effectively prevents colorectal cancer metastasis. It also inhibits tumor growth in human colorectal cancer HCT116 cell xenograft mouse models. MO-2097 is applicable for colorectal cancer research.