MO-2097
Product Specifications
CAS Number
2744300-63-6
Target
ROS|||Apoptosis|||Caspase|||MEK|||ERK|||HIF/HIF Prolyl-Hydroxylase|||Raf
Related Pathways
Immunology/Inflammation|||Metabolism|||Apoptosis|||Proteases/Proteasome|||Chromatin/Epigenetic|||MAPK
Bioactivity
MO-2097 is an inhibitor of RAF-1 and HIF-1?. It destabilizes RAF-1, reducing EMT-related transcription factors and mesenchymal markers. MO-2097 suppresses HIF-1? protein expression under hypoxic or hypoxia-mimicking conditions via hnRNPA2B1. It induces mitochondrial ROS production, leading to cell apoptosis. By inhibiting the RAF/MEK/ERK signaling pathway, MO-2097 effectively prevents colorectal cancer metastasis. It also inhibits tumor growth in human colorectal cancer HCT116 cell xenograft mouse models. MO-2097 is applicable for colorectal cancer research.
Smiles
OC=1C=C(O)C=C(C1)C=2OC=3C=C4OCC(=CCC4=CC3C2)C
Molecular Formula
C19H16O4
Molecular Weight
308.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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