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Hyrtiosal

Product Specifications

CAS Number

138355-07-4

Target

HIV Protease

Related Pathways

Microbiology/Virology, Proteases/Proteasome

Bioactivity

Hyrtiosal, discovered in the marine sponge Hyrtios erectus, is an inhibitor of HIV-1 integrase (HIV-1IN) at the N-terminal domain (NTD), exhibiting an IC50 value of 9.60-0.86 μM. It binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1IN, thereby preventing the integration of HIV-1 viral DNA with the enzyme and disrupting the formation of the HIV-1 pre-integration complex. Hyrtiosal holds potential for research as an anti-HIV agent.

Smiles

C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)CCC3)[H])(C[C@@](C=O)(C)[C@H]2C[C@H](O)C=4C=COC4)[H]

Molecular Formula

C25H38O3

Molecular Weight

386.57

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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