Nocathiacin II

Nocathiacin II (Nocathiacine II) exhibits significant resistance against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), and multidrug-resistant Enterococcus faecium (MREF) .

O=C1C2=C3C=4C(N2)=CC=CC4COC(=O)[C@@H](O[C@H]5C[C@](C)(O)[C@H](N(C)C)[C@H](C)O5)[C@@](OC3)([C@]6(C7=NC(C(=O)N[C@@](CO1)(C8=NC(=CS8)C=9C(C%10=NC(=CS%10)C(=O)N[C@@]([C@@H](C)O)(C(=O)N\C(=C(\OC)/C)\C%11=NC(C(=O)N6)=CS%11)[H])=CC(O)=C(N9)C%12=NC(C(NC(C(N)=O)=C)=O)=CS%12)[H])=CS7)[H])[H]