Artobiloxanthone
Product Specifications
Target
MMP, COX, STAT, Apoptosis, Bcl-2 Family, Caspase
Related Pathways
JAK/STAT signaling, Neuroscience, Apoptosis, Proteases/Proteasome, Immunology/Inflammation, Stem Cells
Bioactivity
Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC) . It inhibits the Akt/mTOR and STAT3 pathways, thereby suppressing the proliferation of SAS and T.Tn cells with IC50 values of 11 and 22 μM, respectively, as well as cancer cell migration. Artobiloxanthone induces cell apoptosis in OSCC by activating caspase3/9 and causes cell cycle arrest at the S phase.
Molecular Formula
C25H22O7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC042434-500 1x 500 µL
Guanine nucleotide-binding protein alpha-q / GNAQ / G-ALPHA-q (GNAQ/2434), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472092-500 1x 500 µL
P53 Tumor Suppressor Protein (TP53/2092R), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 