Artobiloxanthone
Product Specifications
Target
MMP, COX, STAT, Apoptosis, Bcl-2 Family, Caspase
Related Pathways
JAK/STAT signaling, Neuroscience, Apoptosis, Proteases/Proteasome, Immunology/Inflammation, Stem Cells
Bioactivity
Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC) . It inhibits the Akt/mTOR and STAT3 pathways, thereby suppressing the proliferation of SAS and T.Tn cells with IC50 values of 11 and 22 μM, respectively, as well as cancer cell migration. Artobiloxanthone induces cell apoptosis in OSCC by activating caspase3/9 and causes cell cycle arrest at the S phase.
Molecular Formula
C25H22O7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
S1015-30M 50 µg
SMOC1, Recombinant, Mouse (SPARC-related Modular Calcium-binding Protein 1, Secreted Modular Calcium-binding Protein 1, SMOC-1)
Sign In for Pricing
View Details 
LEB93943 250 mg
5- (((4-ethoxyphenyl) amino) methylene) -1,3-diazaperhydroine-2,4,6-trione
Sign In for Pricing
View Details 
MBS3030030-01 5 mg
Anti-ICAM-1 In Vivo Antibody - Ultra Low Endotoxin (15.2)
Sign In for Pricing
View Details MBS3030030-02 25 mg
Anti-ICAM-1 In Vivo Antibody - Ultra Low Endotoxin (15.2)
Sign In for Pricing
View Details