Nocathiacin I

Nocathiacin I (Nocathiacine I) exhibits strong resistance against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), and multidrug-resistant Enterococcus faecium (MREF) .

ON1C=2C=3C4=C1C(=O)OC[C@]5(C6=NC(=CS6)C=7C(C8=NC(=CS8)C(=O)N[C@@]([C@@H](C)O)(C(=O)N\C(=C(\OC)/C)\C9=NC(C(=O)N[C@@]([C@](OC4)([C@H](O[C@H]%10C[C@](C)(O)[C@H](N(C)C)[C@H](C)O%10)C(=O)OCC3C=CC2)[H])(C%11=NC(C(=O)N5)=CS%11)[H])=CS9)[H])=CC(O)=C(N7)C%12=NC(C(NC(C(N)=O)=C)=O)=CS%12)[H]