Hexacyclinol
Product Specifications
CAS Number
903574-41-4
Target
Parasite, Antibiotic, Antibacterial
Related Pathways
Microbiology/Virology
Bioactivity
Hexacyclinol exhibits moderate activity against Gram-positive bacteria and can inhibit oxidant production in yeast polysaccharide-stimulated polymorphonuclear leukocytes (PMNL) at concentrations of 4–40 μg/mL. It suppresses the growth of L-930 and K562 cells with IC50 values of 1.4 μg/mL and 0.4 μg/mL, respectively, and has an IC50 of 10 μg/mL for HeLa cells. Additionally, Hexacyclinol shows antimalarial activity, with an IC50 of 2.4 μg/mL against Plasmodium falciparum.
Smiles
C(OC)(C)(C)[C@@H]1[C@@]23[C@@]([C@@](O[C@@H]2C=C(C)C)([C@]4([C@@](C3=O)(O4)[H])[H])[H])([C@]5(C(=C1)C(=O)[C@@]6([C@]([C@@H]5O)(O6)[H])[H])[H])[H]
Molecular Formula
C23H28O7
Molecular Weight
416.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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