Triptriolide
Product Specifications
CAS Number
137131-18-1
Target
NF-κB, Apoptosis, MAPK, MAP3K
Related Pathways
MAPK, Apoptosis, NF-κB
Bioactivity
Triptriolide inhibits puromycin aminonucleoside (PAN) -induced apoptosis in mouse podocytes by modulating Bcl-2 family proteins and suppressing Caspase-3. It also promotes cell survival and protects podocyte function by activating the TAK1-NF-κB signaling pathway and upregulating the podocyte protein podocin.
Smiles
C[C@@]12[C@@]34[C@@]5([C@@](O5)(C[C@]1(C6=C(CC2)C(=O)OC6)[H])[H])[C@H](O)[C@@]([C@@H](C)C)(O)[C@H](O)[C@@]3(O4)[H]
Molecular Formula
C20H26O7
Molecular Weight
378.416
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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