Clavariopsin B

Clavariopsin B is a cyclic peptide antibiotic exhibiting antifungal activity. It is effective against Candida albicans [IFO 0583], Candida albicans [ATCC 10231], Aspergillus niger [AJ117374], Aspergillus fumigatus [AJ117190], and Aspergillus fumigatus [JCM1739], with minimum inhibitory concentrations (MICs) of 8, 8, 16, 4, and 4 μg/mL respectively.

O=C1N2[C@](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(O)=O)C(=O)N(C)[C@@]([C@H](CC)C)(C(=O)N(C)[C@@]([C@H](CC)C)(C(=O)NCC(=O)N(C)[C@@H](C(C)C)C(=O)N[C@@H](CC3=CC=C(OC)C=C3)C(=O)O[C@@H]1C(C)C)[H])[H])(CCCC2)[H]