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Gypsetin

Product Specifications

CAS Number

155114-38-8

Target

Acyltransferase

Related Pathways

Metabolism

Bioactivity

Gypsetin inhibits the activity of acyl-CoA:cholesterol acyltransferase (ACAT), showing inhibitory effects on rat liver microsomal ACAT with an IC50 of 18 ?M, and competes with oleoyl-CoA substrate, possessing a Ki value of 5.5 ?M. Additionally, Gypsetin prevents the formation of cholesterol esters from oleic acid with an IC50 of 0.65 ?M.

Smiles

[C@@](C=C)(C)(C)[C@]12[C@](O)(C=3C(N1)=CC=CC3)C[C@@]4(N2C(=O)[C@]5(N(C4=O)[C@]6(C(C=C)(C)C)[C@](O)(C5)C=7C(N6)=CC=CC7)[H])[H]

Molecular Formula

C32H36N4O4

Molecular Weight

540.653

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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