Vinflunine
Product Specifications
CAS Number
162652-95-1
UNSPSC Description
Vinflunine is a type of fluorinated vinca alkaloid that has the ability to block mitosis and interact with tubulin[1][2][3].
Target Antigen
Microtubule/Tubulin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vinflunine.html
Solubility
10 mM in DMSO
Smiles
CC[C@@]12[C@@]3([H])[C@]4(CCN3CC=C2)[C@](N(C5=CC(OC)=C([C@@]6(C7=C(C[N@@]8C[C@](C[C@H](C8)C(F)(F)C)([H])C6)C9=CC=CC=C9N7)C(OC)=O)C=C54)C)([H])[C@](O)([C@@H]1OC(C)=O)C(OC)=O
Molecular Weight
816.93
References & Citations
[1]Ngan, V.K., et al., Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. Cancer Res, 2000. 60(18): p. 5045-51.|[2]Lobert, S., et al., Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line. Biochemistry, 2000. 39(39): p. 12053-62.|[3]Kruczynski, A., et al., Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur J Cancer, 2006. 42(16): p. 2821-32.
Shipping Conditions
Room temperature
Clinical Information
Launched
Frequently Asked Questions
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