BI 689648
Product Specifications
UNSPSC Description
BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively.
Target Antigen
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/BI_689648.html
Purity
99.20
Solubility
DMSO : 30 mg/mL (ultrasonic;warming)
Smiles
O=C(N1CCCC2=C1N=CC(C3=CC(COC)=CN=C3)=C2)N
Molecular Weight
298.34
References & Citations
[1]Weldon SM, et al. Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates. J Pharmacol Exp Ther. 2016 Oct;359(1):142-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101217/BI-689648-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101217/BI-689648-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1633009-87-6
Available Sizes
Curated Selection
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