BI 689648

BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively.

Product Specifications

CAS Number

[1633009-87-6]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/BI_689648.html

Purity

99.20

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

O=C(N1CCCC2=C1N=CC(C3=CC(COC)=CN=C3)=C2)N

Molecular Formula

C16H18N4O2

Molecular Weight

298.34

References & Citations

[1]Weldon SM, et al. Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates. J Pharmacol Exp Ther. 2016 Oct;359 (1) :142-50.