Fezolinetant
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
Product Specifications
CAS Number
[1629229-37-3]
Product Name Alternative
ESN-364
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Fezolinetant.html
Purity
99.19
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(N1[C@H](C)C2=NN=C(C3=NC(C)=NS3)N2CC1)C4=CC=C(F)C=C4
Molecular Formula
C16H15FN6OS
Molecular Weight
358.39
Precautions
H315, H319
References & Citations
[1]Fraser GL, et al. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 2015 Nov;156 (11) :4214-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
NK3R
Available Sizes
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