B2M/beta 2-Microglobulin Protein, Mouse, Recombinant (hFc)

The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX) . Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors.