Thioridazine (hydrochloride)

Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) [1][2][3][4].

Product Specifications

CAS Number

[130-61-0]

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor; Apoptosis; Autophagy; Bacterial; Dopamine Receptor

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Thioridazine-hydrochloride.html

Purity

99.96

Solubility

DMSO : ≥ 45 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

CSC(C=C1N2CCC3N(C)CCCC3)=CC=C1SC4=C2C=CC=C4.[H]Cl

Molecular Formula

C21H27ClN2S2

Molecular Weight

407.04

Precautions

H302

References & Citations

[1]Tschanz JT, et, al. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol Biochem Behav. 1988 Nov;31 (3) :519-22.|[2]Mu J, et, al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. Oncol Rep. 2014 May;31 (5) :2107-14.|[3]Aguilar-Vega L, et, al. Antibacterial properties of phenothiazine derivatives against multidrug-resistant Acinetobacter baumannii strains. J Appl Microbiol. 2021 Apr 22.|[4]Kang S, et, al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep;17 (9) :989-97.|[5]Loehr AR, et, al. Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. Cancers (Basel) . 2021 Apr 23;13 (9) :2045.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

MUC4

Citation 01

BioRxiv. 2025 Nov 21:2025.11.20.689520.|Br J Cancer. 2024 Oct;131 (7) :1212-1223.|Int J Biol Macromol. 2022 Feb 15:198:1-10.|Pol J Microbiol. 2019 Dec;68 (4) :477-491.|Int J Mol Sci. 2023 Jan 13;24 (2) :1635.