TGS1 Protein, Human, Recombinant (His & SUMO)
Product Specifications
Bioactivity
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m (7) G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m (2,2,7) G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs) . Plays a role in transcriptional regulation.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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