PhoP Protein, E. coli, Recombinant (HEK293, His & Myc)

Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg (2+) environments and the control of acid resistance genes. In low periplasmic Mg (2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG) . In high periplasmic Mg (2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes.