Capecitabine-d11
Product Specifications
CAS Number
1132662-08-8
Target
DNA/RNA Synthesis|||Nucleoside Antimetabolite/Analog|||Apoptosis
Related Pathways
Apoptosis|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint
Bioactivity
Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU) ; subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.
Smiles
O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)N=C(NC(OC(C(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])=O)C(F)=C2
Molecular Formula
C15H11D11FN3O6
Molecular Weight
370.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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