Beclometasone dipropionate

Beclometasone dipropionate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma [1][2].

Product Specifications

CAS Number

[5534-09-8]

Product Name Alternative

Beclomethasone dipropionate

UNSPSC

12352211

Hazard Statement

H361, H373

Target

Glucocorticoid Receptor; NO Synthase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Beclometasone-dipropionate.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C[C@@]12[C@](C[C@H](C)[C@]2(OC(CC)=O)C(COC(CC)=O)=O)([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C1)=O

Molecular Formula

C28H37ClO7

Molecular Weight

521.04

Precautions

H361, H373

References & Citations

[1]Hrvacić B, et, al. Applicability of an ultrasonic nebulization system for the airways delivery of beclomethasone dipropionate in a murine model of asthma. Pharm Res. 2006 Aug;23 (8) :1765-75. |[2]Montalbano AM, et, al. Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells. Eur J Pharmacol. 2013 Oct 15;718 (1-3) :418-27.