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PARP10/15-IN-3

PARP10/15-IN-3 (Compound 8a) is a potent PARP10 and PARP15 dual inhibitor with IC50 values of 0.14 µM and 0.40 µM against PARP10 and PARP15, respectively. PARP10/15-IN-3 is able to enter cells and rescue cells from apoptosis[1].

Product Specifications

CAS Number

2892064-88-7

UNSPSC

12352005

Target

Apoptosis; PARP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp10-15-in-3.html

Concentration

10mM

Purity

99.23

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NNC(C2=C1C=CC(OCC3CCCCC3)=C2)=O

Molecular Formula

C15H18N2O3

Molecular Weight

274.32

References & Citations

[1]Nizi MG, et al. Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem. 2022 Jul 5;237:114362.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP10; PARP15

Available Sizes

Frequently Asked Questions

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