ND-646

ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

Product Specifications

CAS Number

[1434639-57-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Acetyl-CoA Carboxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ND-646.html

Purity

99.13

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC=CO5)S3)=O)C4=O

Molecular Formula

C28H32N4O7S

Molecular Weight

568.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Svensson RU, et al. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 Oct;22 (10) :1108-1119.