Lipid TG4C
Product Specifications
CAS Number
3028336-07-1
Target
Others
Related Pathways
Others
Bioactivity
Lipid TG4C, an ionizable cationic glycerolipid (pKa = 6.71), has been utilized for creating lipid nanoparticles (LNPs) designed to deliver mRNA in vivo. In mice, these LNPs containing lipid TG4C and mRNA encoding human erythropoietin (EPO) result in increased serum EPO levels. Additionally, inhalation of LNPs with lipid TG4C carrying mRNA for human hepatocyte growth factor (HGF) decreases levels of Il-1β, Il-6, and Tnf-α in bronchoalveolar lavage fluid (BALF) in a mouse model of pulmonary emphysema induced by porcine pancreatic elastase.
Smiles
O=C(OCC(OC(=O)CCCN(C)C)COC(=O)CCCCC(=O)OC(CCCCCCCC)CCCCCCCC)CCCCC(=O)OC(CCCCCCCC)CCCCCCCC
Molecular Formula
C55H103NO10
Molecular Weight
938.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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