Divarasib
Product Specifications
CAS Number
2417987-45-0
Target
Ras, Kras
Related Pathways
MAPK, GPCR/G Protein
Purity
0.9996
Bioactivity
Divarasib (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibits tumor cell growth. It is being investigated for use in solid tumors, including non-small cell lung and colorectal cancers and other types of cancer.
Smiles
C[C@H]1CN(CCN1c1nc(OC[C@@H]2CCCN2C)nc2c(F)c(c(Cl)cc12)-c1nc(N)cc(C)c1C(F)(F)F)C(=O)C=C
Molecular Formula
C29H32ClF4N7O2
Molecular Weight
622.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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