MHES0488A
Product Specifications
Target
EGFR, DNA Alkylator/Crosslinker
Related Pathways
DNA Damage/DNA Repair, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
MHES0488A is a selective humanized antibody targeting HER2, with a KD value of 0.8 nM. It constitutes the antibody portion of DHES0815A. Upon cellular internalization, MHES0488A is transported to lysosomes, releasing PBD-monoamide into the nucleus, where it alkylates DNA, inducing DNA damage and apoptosis. It shows potential for research in cancers such as HER2-positive breast cancer and gastric cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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