What is the catalog number for MHES0488A?

The catalog number for MHES0488A is T9901A-980.

What sizes are available for MHES0488A?

MHES0488A is available in the following size(s): 1 mg, 5 mg.

How many pack sizes does MHES0488A come in?

MHES0488A is available in 2 different pack sizes.

Is MHES0488A in stock?

MHES0488A is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MHES0488A?

MHES0488A is manufactured by Molfinity.

What is the estimated delivery time for MHES0488A?

Estimated delivery time for MHES0488A is approximately 10 business day(s), depending on your location.

MHES0488A

Product Specifications

Target

EGFR, DNA Alkylator/Crosslinker

Related Pathways

DNA Damage/DNA Repair, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

Bioactivity

MHES0488A is a selective humanized antibody targeting HER2, with a KD value of 0.8 nM. It constitutes the antibody portion of DHES0815A. Upon cellular internalization, MHES0488A is transported to lysosomes, releasing PBD-monoamide into the nucleus, where it alkylates DNA, inducing DNA damage and apoptosis. It shows potential for research in cancers such as HER2-positive breast cancer and gastric cancer.