COVA208
Product Specifications
Target
Akt, p38 MAPK, EGFR, PI3K
Related Pathways
Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, MAPK, Angiogenesis, JAK/STAT signaling, PI3K/Akt/mTOR signaling
Bioactivity
COVA208 is a bispecific FynomAb targeting HER2, consisting of a fusion protein of an antibody and a FynSH3-derived binding protein. It induces the degradation of HER2, reducing the levels of HER2, HER3, and EGFR, effectively blocking downstream signaling pathways such as HER3-PI3K-AKT and MAPK, and inducing apoptosis in tumor cells. COVA208 shows promise for research in cancers like HER2-positive breast, gastric, and colorectal cancers.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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