NC762

NC762 is a humanized IgG1? monoclonal antibody that targets human B7-H4 (B7 homolog 4) . Its Fc region contains three point mutations (S239D/A330L/I332E; DLE) to enhance binding to CD16a (Fc?RIIIa), leading to increased antibody-dependent cellular cytotoxicity (ADCC) . By binding to tumor-expressed B7-H4, NC762 inhibits tumor growth in vivo. This compound can be utilized in research on advanced or metastatic solid tumors.