LE01
Product Specifications
CAS Number
2718125-83-6
Target
Drug-Linker Conjugates for ADC, Topoisomerase
Related Pathways
DNA Damage/DNA Repair, Antibody-drug Conjugate/ADC Related
Bioactivity
LE01 is a component of the antibody-drug conjugate (ADC) known as a drug-linker conjugate for ADC. It comprises an ADC linker and the DNA topoisomerase I inhibitor DXd. LE01 is used in the synthesis of the HER2-targeting antibody-drug conjugate named HER2-LE01.
Smiles
N(C(COC(N(CCNC(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(=O)C=CC2=O)=O)=O)=O)=O)=O)C)=O)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8
Molecular Formula
C55H61FN10O14
Molecular Weight
1105.13
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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