AG01

PI3K/Akt/mTOR signaling|||MAPK|||Angiogenesis|||Proteases/Proteasome|||Metabolism|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors

AG01 is a monoclonal antibody targeting the anti-granular protein precursor (GP88) . It inhibits the proliferation and migration of triple-negative breast cancer (TNBC) cells, reducing the expression of phosphorylated protein kinases such as p-Src, p-AKT, and p-ERK, as well as oncogenic proteins like Axl, c-MET, HIF-1?, and VEGF. In TNBC xenograft mouse models, AG01 suppresses tumor growth and the expression of Ki67 in vivo. AG01 is useful for research involving cancers like TNBC.